Download PDF by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy: Advances in Virus Research, Vol. 72

By Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy

ISBN-10: 0123743222

ISBN-13: 9780123743220

Released seeing that 1953, Advances in Virus learn covers a various diversity of in-depth stories delivering a important evaluation of the present box of virology. The impression issue for 2006 is 3.48 putting it seventh within the hugely aggressive class of virology. * Contributions from top gurus * Informs and updates on the entire most recent advancements within the box

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Extra info for Advances in Virus Research, Vol. 72

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Virus neutralization) against DENV infection, albeit epidemiologically well-founded, lacks an inherent understanding of human antibody responses during primary or heterotypic DENV infections. This gap is mainly attributed to our lack of knowledge of the precise identity of cells that support DENV replication, as well as their contribution to disease during the early events of DENV infection. Subsequently very little is known about any biologically relevant receptor(s) responsible for attachment and entry of DENV into human cells.

1999). This study provided strong epidemiological evidence of the limited pathogenicity of the American genotype, even during secondary infection. Because the Asian genotypes had not yet reached this region of Peru, their possible competitive advantage for viremia and mosquito infection could not be evaluated. , soluble nonstructural protein 1 [sNS1]) in the bloodstream of the infected. Early studies by Halstead (Halstead, 1988; Rosen, 1986) hypothesized an association between virulence (disease severity) and virus load.

The analysis revealed that the E gene of DENV-2 is 48 Nikos Vasilakis and Scott C. Weaver subject to strong purifying selective constraints (expressed as the extremely low ratio of dN/dS), with evidence of weak positive selection in the Cosmopolitan (1 site) and lineage 2 (17 sites) of the Asian genotypes. 056), which suggests that increased fitness may correlate with their dispersal potential. Of particular interest was the positively selected E390 site within the Cosmopolitan genotypes, which has been previously identified as a key virulence determinant (Sanchez and Ruiz, 1996) and maps within the distal face of domain III, a region associated with viral attachment to host cells.

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Advances in Virus Research, Vol. 72 by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy


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