By George F. Vande Woude, George Klein
Advances in melanoma study presents priceless details at the intriguing and fast-moving box of melanoma learn. right here once more, extraordinary and unique studies are provided. Key positive aspects * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and medical Implications of the Erb/HER Signaling community of progress issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic price * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability
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Extra resources for Advances in Cancer Research, Vol. 77
Taken together, these initial clinical correlates of ErbB-3 attribute to it a role in carcinoma development, which may differ from that of ErbB-2. Given the necessity of ErbB-3 heterodimerization, the true role of ErbB-3 overexpression as a prognostic factor might be better clariﬁed if coexpression with ErbB-2 were analyzed. , 1996). ErbB-4 Only a few clinical studies of ErbB-4 are available. Consistent 32 Leah N. Klapper et al. , 1997). Even more important, coexpression with ErbB-2 was found in 54% of tumors, but neuregulin expression was limited to 31% of cancers, and no correlation with clinicopathological disease features was observed.
Although lymph node status per se is the major prognostic factor indicating future relapse, even in lymph node negative breast cancer 30% of patients will relapse. Thus, it is imperative to determine other prognostic indicators that could identify which patients may have a more aggressive disease that requires more intensive treatment. The amount of ErbB-2, especially when analyzed in relatively large groups of patients (Ͼ300 specimens), appears to predict clinical outcome in both node negative and node positive patients, and thus may serve as a useful indicator.
Klapper et al. , 1997) and 30–50% of ovarian cancers express ErbB-2. , 1992). , 1989). , 1997). , 1997). , 1992), and more often than in breast cancer, overexpression may not be linked to gene ampliﬁcation. , 1995). , 1997). 2. , 1997). , 1997). , 1998). , 1998). , 1995). As in the case of ovarian and breast cancer, these results may be technique dependent. , 1997). 3. , 1996). , 1990b). , 1990b). , 1991). , 1997). , 1997). C. , 1993). , 1996). In fact, discrimination between membrane or cytoplasmic staining may yield an even stronger difference between benign and malignant tissue.
Advances in Cancer Research, Vol. 77 by George F. Vande Woude, George Klein