Read e-book online Acute Leukemias V: Experimental Approaches and Management of PDF

By Leo Sachs (auth.), Prof. Dr. W. Hiddemann, Priv.-Doz. Dr. W. Plunkett, Prof. Dr. T. Büchner, Prof. Dr. J. Ritter, B. Wörmann M.D., Ph.D., M. J. Keating M.D., B.S., Prof. Dr. U. Creutzig (eds.)

ISBN-10: 3642789072

ISBN-13: 9783642789076

ISBN-10: 3642789099

ISBN-13: 9783642789090

This quantity, the 5th in a sequence on acute leukemias, focuses quite on fresh uncomplicated examine effects and novel healing methods to the affliction. points of leukemia mobilephone biology, together with differentiation, the mechanisms of drug resistance, the pharmacology of cytostatic brokers and the result of scientific trials in relapsed and refractory ailment are lined through impressive overseas specialists within the respective fields. destiny advancements together with new brokers and new treatment plans comparable to unrelated bone marrow transplantation, immunotargeting and gene treatment whole a cutting-edge summery of present wisdom in experimental leukemia therapy.

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Additional resources for Acute Leukemias V: Experimental Approaches and Management of Refractory Disease

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S. Hokland P: Monoclonal antibody ratios in malignant myeloid diseases: diagnostic and prognostie use in myelodysplastie syndromes. Br. J. Haematol74, 270-276, 1990 DeIwel R, Löwenberg B: Variable differentiation of human acute myeloid leukemia during colony formation in vitro: A membrane marker analysis with monoclonal antibodies. Brit J Haematol59: 37 1985 Masuya M, Kita K, Shimizu N, Ohishi K, Katayama N, Sekine T. Otsuji A, Miwa H. Shirakawa S: Biologie characteristics of acute leukemia after myelodysplastic syndrome.

The molecular correlate of t(4;1l) is a fusion gene composed of HRX (ALL-I, MLL) on llq23 and FEL (AF-4) on 4q21. HRX shows homology to Drosophila trithorax, and to murine ALL-I and most likely represents a DNA-binding transactivating factor of unknown function in human hematopoiesis and/or embryogenesis. Replacement of 3' zinc finger domains of HRX by 3' pro tein domains of the FEL fusion partner may alter protein-DNA interaction specificity and thereby confer transforming potential to HRX fusion proteins.

Sachs 1. 1970. In vitro control of growth and development of hematopoietic cell clones. In: Regulation of Hematopoiesis, Vol. S. Gordon, ed. New York: Appleton-Century-Crofts, 217-233. 19. Sachs 1. 1974. Regulation of membrane changes, differentiation and malignancy in careinogenesis. Harvey Lectures, Vol. 68, New York: Academic Press, 1-35. 20. , Sachs 1. 1971. Characterization of the inducer required for the development of macrophage and granulocyte colonies. Proc. Natl. Acad. Sei. USA 68: 2540-2544.

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Acute Leukemias V: Experimental Approaches and Management of Refractory Disease by Leo Sachs (auth.), Prof. Dr. W. Hiddemann, Priv.-Doz. Dr. W. Plunkett, Prof. Dr. T. Büchner, Prof. Dr. J. Ritter, B. Wörmann M.D., Ph.D., M. J. Keating M.D., B.S., Prof. Dr. U. Creutzig (eds.)


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